skip to main content

Recurrent gout — USMLE Step 3 MCQ

Instant feedback + full explanation. One question, done properly.

HardAmbulatory Medicine / Primary CareRecurrent goutUSMLE Step 3

A patient has had three gout flares in the past year, serum urate 9.4 mg/dL and eGFR 68 mL/min/1.73 m2. The acute flare has resolved. What long-term strategy is most appropriate?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: DStart allopurinol with flare prophylaxis and titrate to serum urate target

Explanation lettering: E = shown as A · D = shown as B · A = shown as D · B = shown as E

Recurrent flares support urate-lowering therapy, commonly allopurinol, with prophylaxis during initiation. B is insufficient alone. C increases urate. D and E do not treat gout pathophysiology.

Reference: American College of Rheumatology, Gout Guideline: https://rheumatology.org/gout-guideline