Simple febrile seizure — USMLE Step 3 MCQ

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HardPediatrics (well-child, chronic management)Simple febrile seizureUSMLE Step 3

A 70-kg adult requires the FDA three-bag IV acetylcysteine regimen. Which sequence is correct?

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Correct answer: C — 10.5 g over 1 hour, 3.5 g over 4 hours, then 7 g over 16 hours

The best answer is “10.5 g over 1 hour, 3.5 g over 4 hours, then 7 g over 16 hours”. Multiplying 70 kg by 150, 50, and 100 mg/kg yields the three doses. The 21-hour three-bag IV acetylcysteine regimen is 150 mg/kg over 1 hour, 50 mg/kg over 4 hours, then 100 mg/kg over 16 hours. The alternatives use a different threshold, timing, population, or intervention and therefore do not match the clinical facts presented.

Reference: FDA: Acetadote Prescribing Information: https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/021539s021lbl.pdf