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Chronic hepatitis C — USMLE Step 3 MCQ

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ModerateInternal Medicine (Chronic Management)Chronic hepatitis CUSMLE Step 3

A 36-year-old man has positive HCV antibody and detectable HCV RNA. ALT is mildly elevated. Noninvasive testing shows no cirrhosis and HIV testing is negative. He drinks no alcohol and wants treatment. Which of the following is the most appropriate next step in management?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Treat with a direct-acting antiviral regimen

Most patients with chronic HCV infection should receive direct-acting antiviral therapy after pretreatment evaluation.

Reference: Current US clinical practice standards and USMLE Step 3 content outline, https://www.usmle.org/exam-resources/step-3-materials