skip to main content

Thyroid nodule — USMLE Step 3 MCQ

Instant feedback + full explanation. One question, done properly.

ModerateSurgery (Post-operative / Follow-up)Thyroid noduleUSMLE Step 3

A 49-year-old woman has a 1.8-cm solid hypoechoic thyroid nodule with irregular margins on ultrasound. TSH is normal. She has no compressive symptoms or medullary thyroid cancer family history. Which of the following is the most appropriate next step in management?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: DPerform fine-needle aspiration biopsy

A suspicious thyroid nodule of sufficient size with normal TSH should undergo ultrasound-guided FNA.

Reference: Current US clinical practice standards and USMLE Step 3 content outline, https://www.usmle.org/exam-resources/step-3-materials