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Medication-overuse headache — USMLE Step 3 MCQ

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ModerateInternal Medicine (Chronic Management)Medication-overuse headacheUSMLE Step 3

A 40-year-old woman has 18 headache days monthly, with migrainous features on 10 days. She uses ibuprofen almost daily and triptans 12 days monthly. Neurologic examination is normal. Which of the following is the most likely explanation for this patient's findings?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: CMedication overuse contributing to chronic migraine

Frequent analgesic and triptan use can perpetuate chronic migraine through medication-overuse headache.

Reference: Current US clinical practice standards and USMLE Step 3 content outline, https://www.usmle.org/exam-resources/step-3-materials