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Kawasaki disease — USMLE Step 3 MCQ

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HardPediatrics (Well-child / Chronic Management)Kawasaki diseaseUSMLE Step 3

A healthy infant is born at 38 weeks in November. The mother received maternal RSVpreF vaccine 10 days before delivery. The newborn has no contraindication to monoclonal antibody administration. Which prevention plan is recommended before discharge?

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Correct answer: E — Administer an infant long-acting RSV antibody during the newborn birth hospitalization

The best answer is “Administer an infant long-acting RSV antibody during the newborn birth hospitalization”. At least 14 days are needed for development and placental transfer of protective antibody after maternal vaccination. An infant born within 14 days of maternal RSV vaccination remains eligible for a long-acting infant RSV antibody. For a birth during the usual October-through-March season, administration is ideally completed during the birth hospitalization. Most infants born at least 14 days after maternal vaccination do not need both products.

Reference: CDC RSV Immunization Guidance for Infants and Young Children: https://www.cdc.gov/rsv/hcp/vaccine-clinical-guidance/infants-young-children.html