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Adrenal insufficiency sick-day rules — USMLE Step 3 MCQ

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HardInternal Medicine (Chronic Management)Adrenal insufficiency sick-day rulesUSMLE Step 3

A patient with established primary adrenal insufficiency takes hydrocortisone 20 mg each morning and 10 mg each afternoon and is scheduled for open colectomy. Which perioperative glucocorticoid plan is appropriate?

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Correct answer: CGive intravenous hydrocortisone 100 mg at induction and 200 mg over the next 24 hours

The best answer is “Give intravenous hydrocortisone 100 mg at induction and 200 mg over the next 24 hours”. Major surgery imposes stress that usual replacement cannot cover. The recommended regimen is 100 mg IV hydrocortisone at induction followed by 200 mg during 24 hours, then tapering toward baseline as recovery permits.

Reference: Endocrine Society Clinical Practice Guideline: Primary Adrenal Insufficiency: https://www.endocrine.org/clinical-practice-guidelines/primary-adrenal-insufficiency