Adrenal insufficiency sick-day rules — USMLE Step 3 MCQ
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Correct answer: C — Give intravenous hydrocortisone 100 mg at induction and 200 mg over the next 24 hours
The best answer is “Give intravenous hydrocortisone 100 mg at induction and 200 mg over the next 24 hours”. Major surgery imposes stress that usual replacement cannot cover. The recommended regimen is 100 mg IV hydrocortisone at induction followed by 200 mg during 24 hours, then tapering toward baseline as recovery permits.
Reference: Endocrine Society Clinical Practice Guideline: Primary Adrenal Insufficiency: https://www.endocrine.org/clinical-practice-guidelines/primary-adrenal-insufficiency