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Massive PE — USMLE Step 3 MCQ

Instant feedback + full explanation. One question, done properly.

HardEmergency MedicineMassive PEUSMLE Step 3

A 54-year-old woman has sudden dyspnea and syncope after recent hip surgery. Blood pressure is 78/44 mm Hg and oxygen saturation is 86%. CT angiography shows large bilateral pulmonary emboli with right ventricular strain. Which of the following is the most appropriate next step in management?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: AAdminister systemic thrombolysis

Massive PE with hemodynamic instability requires reperfusion therapy when not contraindicated.

Reference: Current US clinical practice standards and USMLE Step 3 content outline, https://www.usmle.org/exam-resources/step-3-materials