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Diabetic neuropathy — USMLE Step 3 MCQ

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ModerateInternal Medicine (Chronic Management)Diabetic neuropathyUSMLE Step 3

A 60-year-old woman with diabetes reports burning pain in both feet at night. Examination shows decreased vibration and pinprick in a stocking distribution. B12 and TSH are normal and pedal pulses are intact. Which of the following is the most appropriate next step in management?

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Correct answer: BStart duloxetine or pregabalin for neuropathic pain

Painful diabetic peripheral neuropathy is treated with neuropathic pain agents such as duloxetine or pregabalin.

Reference: ADA Standards of Care in Diabetes 2026, https://professional.diabetes.org/standards-of-care