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Latent TB — USMLE Step 3 MCQ

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HardInternal Medicine (Chronic Management)Latent TBUSMLE Step 3

A 33-year-old healthcare worker has a positive interferon-gamma release assay after exposure. Chest radiograph is normal and she has no symptoms; HIV test is negative. What is the best next step?

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Correct answer: A — Offer latent-tuberculosis treatment after excluding active disease by clinical evaluation

A positive IGRA with no clinical or radiographic evidence of active disease indicates latent tuberculosis infection. After excluding active disease, a recommended preventive regimen should be offered.

Reference: CDC, Treatment for Latent Tuberculosis Infection: https://www.cdc.gov/tb/hcp/treatment/latent-tuberculosis-infection.html