Bipolar I disorder — USMLE Step 3 MCQ
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Correct answer: C — Begin eating-disorder-focused CBT plus fluoxetine titrated to 60 mg daily
The best answer is “Begin eating-disorder-focused CBT plus fluoxetine titrated to 60 mg daily”. For adult bulimia nervosa, the recommended combination is eating-disorder-focused CBT and an SRI; fluoxetine 60 mg has the strongest medication evidence. Bupropion is contraindicated because purging increases seizure risk, and treatments used for binge-eating disorder or anorexia are not substitutes.
Reference: APA Practice Guideline for the Treatment of Patients With Eating Disorders: https://psychiatryonline.org/doi/full/10.1176/appi.books.9780890424865.eatingdisorder03