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Bipolar I disorder — USMLE Step 3 MCQ

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HardPsychiatry (Outpatient Management)Bipolar I disorderUSMLE Step 3

A 27-year-old has normal BMI and recurrent binge eating followed by self-induced vomiting four times weekly. Potassium is normal, there is no suicidality, and she accepts outpatient care. Which evidence-based initial plan is most appropriate?

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Correct answer: CBegin eating-disorder-focused CBT plus fluoxetine titrated to 60 mg daily

The best answer is “Begin eating-disorder-focused CBT plus fluoxetine titrated to 60 mg daily”. For adult bulimia nervosa, the recommended combination is eating-disorder-focused CBT and an SRI; fluoxetine 60 mg has the strongest medication evidence. Bupropion is contraindicated because purging increases seizure risk, and treatments used for binge-eating disorder or anorexia are not substitutes.

Reference: APA Practice Guideline for the Treatment of Patients With Eating Disorders: https://psychiatryonline.org/doi/full/10.1176/appi.books.9780890424865.eatingdisorder03