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Rh incompatibility prevention — USMLE Step 3 MCQ

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EasyOB/GYN (prenatal care, contraception, screening)Rh incompatibility preventionUSMLE Step 3

A 26-year-old G2P1 woman at 28 weeks' gestation is Rh-negative and antibody screen is negative. The father is Rh-positive. She has no bleeding. Which of the following is the most appropriate next step in management?

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Correct answer: B — Administer anti-D immune globulin

Unsensitized Rh-negative pregnant patients should receive anti-D immune globulin at approximately 28 weeks and after sensitizing events.

Reference: USPSTF Rh incompatibility screening; ACOG Rh alloimmunization guidance