A 58-year-old man with diabetes starts empagliflozin. Three months later A1c improves and he has lost 6 lb. He reports increased urination. Which of

Question

A 58-year-old man with diabetes starts empagliflozin. Three months later A1c improves and he has lost 6 lb. He reports increased urination. Which of the following is the most likely explanation for this patient's findings?

Accepted Answer

Increased urinary glucose excretion in the proximal tubule

Answer

Delayed gastric emptying through GLP-1 receptor activation

Answer

Blockade of intestinal alpha-glucosidase

Answer

Increased pancreatic insulin secretion through sulfonylurea receptor binding

Answer

Reduced hepatic gluconeogenesis through mitochondrial complex inhibition

SGLT2 inhibitor mechanism — USMLE Step 3 MCQ

A 58-year-old man with diabetes starts empagliflozin. Three months later A1c improves and he has lost 6 lb. He reports increased urination. Which of the following is the most likely explanation for this patient's findings?