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Gastroesophageal reflux disease — USMLE Step 3 MCQ

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EasyAmbulatory Medicine / Primary CareGastroesophageal reflux diseaseUSMLE Step 3

A 46-year-old woman has 3 months of epigastric burning that worsens after meals and improves with antacids. She has no dysphagia, weight loss, gastrointestinal bleeding, anemia, or vomiting. She takes ibuprofen twice weekly. Examination is normal. Which of the following is the most appropriate next step in management?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Begin an 8-week proton pump inhibitor trial

Uncomplicated reflux or dyspepsia without alarm features is managed initially with empiric acid suppression.

Reference: ACG GERD/dyspepsia guidance; USMLE Step 3 Content Outline