skip to main content

Systemic lupus erythematosus — USMLE Step 3 MCQ

Instant feedback + full explanation. One question, done properly.

ModerateInternal Medicine (chronic management)Systemic lupus erythematosusUSMLE Step 3

A 30-year-old woman has fatigue, photosensitive rash, oral ulcers, and symmetric hand arthralgias. Urinalysis shows protein and RBC casts. ANA and anti-dsDNA antibodies are positive. Which of the following is the most likely diagnosis?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Systemic lupus erythematosus

Photosensitivity, oral ulcers, inflammatory arthralgias, nephritic urine sediment, and anti-dsDNA antibodies indicate systemic lupus erythematosus.

Reference: ACR/EULAR systemic lupus erythematosus criteria; USMLE Step 3 Content Outline