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Gastroesophageal reflux disease — USMLE Step 3 MCQ

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HardAmbulatory Medicine / Primary CareGastroesophageal reflux diseaseUSMLE Step 3

A 41-year-old has retrosternal discomfort after meals and sour taste when lying down. Symptoms improve with antacids; ECG is normal, exercise tolerance is unchanged, and there is no dysphagia or weight loss. Which diagnosis is most likely?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: DGastroesophageal reflux disease causing postprandial burning and sour regurgitation

Typical heartburn and regurgitation without alarm features support GERD. The normal exertional history and absence of dysphagia, weight loss, or systemic features make the alternatives less likely.

Reference: ACG Clinical Guideline: Diagnosis and Management of GERD: https://pmc.ncbi.nlm.nih.gov/articles/PMC8754510/