A 68-year-old woman has knee osteoarthritis pain despite weight loss and physical therapy. Radiographs show medial joint-space narrowing. She has

Question

A 68-year-old woman has knee osteoarthritis pain despite weight loss and physical therapy. Radiographs show medial joint-space narrowing. She has chronic kidney disease stage 3 and a prior peptic ulcer bleed. Which of the following is the most appropriate next step in management?

Accepted Answer

Offer intra-articular glucocorticoid injection

Answer

Order rheumatoid factor testing

Answer

Prescribe oxycodone as first-line therapy

Answer

Start chronic oral diclofenac

Answer

Begin long-term oral prednisone

Knee osteoarthritis — USMLE Step 3 MCQ

A 68-year-old woman has knee osteoarthritis pain despite weight loss and physical therapy. Radiographs show medial joint-space narrowing. She has chronic kidney disease stage 3 and a prior peptic ulcer bleed. Which of the following is the most appropriate next step in management?