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Major depressive disorder — USMLE Step 3 MCQ

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EasyPsychiatry (outpatient management)Major depressive disorderUSMLE Step 3

A 32-year-old woman has depressed mood, anhedonia, insomnia, low energy, and poor concentration for 2 months. She denies mania, psychosis, substance use, and suicidal intent. She prefers medication. Which of the following is the most appropriate next step in management?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: DStart an SSRI and arrange follow-up

Moderate major depressive disorder can be treated with pharmacotherapy such as an SSRI, psychotherapy, or both, with follow-up.

Reference: APA and VA/DoD mental health clinical practice guidance