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Levothyroxine administration — USMLE Step 3 MCQ

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EasyAmbulatory Medicine / Primary CareLevothyroxine administrationUSMLE Step 3

A 61-year-old woman returns 6 weeks after starting levothyroxine for primary hypothyroidism. She feels slightly better. TSH has decreased from 18 mIU/L to 7.5 mIU/L. She takes the medication with breakfast and calcium carbonate. Which of the following would you recommend at the follow-up visit?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: ATake levothyroxine on an empty stomach separated from calcium

Calcium impairs levothyroxine absorption, so timing counseling is appropriate before escalating therapy.

Reference: American Thyroid Association hypothyroidism guidance