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Cluster headache — USMLE Step 3 MCQ

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ModerateEmergency MedicineCluster headacheUSMLE Step 3

A 34-year-old man has severe unilateral headache with ipsilateral lacrimation, rhinorrhea, ptosis, and restlessness. Attacks last 45 minutes and occur nightly for 2 weeks. Neurologic examination is normal between attacks. Which of the following is the most likely diagnosis?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: ECluster headache

Short severe unilateral headaches with cranial autonomic symptoms and agitation occurring in clusters suggest cluster headache.

Reference: American Headache Society guidance; USMLE Step 3 Content Outline