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Acute uncomplicated cystitis — USMLE Step 3 MCQ

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EasyAmbulatory Medicine / Primary CareAcute uncomplicated cystitisUSMLE Step 3

A 43-year-old woman has dysuria and urinary frequency for 1 day. She is afebrile and has no flank pain, vaginal discharge, pregnancy, diabetes, or recent instrumentation. Urinalysis shows leukocyte esterase and nitrites. Which of the following is the most appropriate next step in management?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: DTreat empirically with nitrofurantoin

Classic uncomplicated cystitis in a nonpregnant woman can be treated empirically with a recommended oral agent.

Reference: IDSA uncomplicated cystitis guidance; USMLE Step 3 Content Outline