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Subclinical hypothyroidism — USMLE Step 3 MCQ

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ModerateAmbulatory Medicine / Primary CareSubclinical hypothyroidismUSMLE Step 3

A 57-year-old woman has fatigue and mild depression. TSH is 6.8 mIU/L, free T4 is normal, and thyroid peroxidase antibody is negative. She has no goiter, pregnancy, or cardiac disease. Which of the following is the most appropriate at this time?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: ERepeat TSH and free T4 in several months

Mild subclinical hypothyroidism with normal free T4 and TSH below 10 mIU/L is often monitored before treatment decisions.

Reference: American Thyroid Association hypothyroidism guidance