A 55-year-old man has fatigue and arthralgia. Laboratory studies show AST 88 U/L, ALT 94 U/L, fasting transferrin saturation 72%, and ferritin 870

Question

A 55-year-old man has fatigue and arthralgia. Laboratory studies show AST 88 U/L, ALT 94 U/L, fasting transferrin saturation 72%, and ferritin 870 ng/mL. He has hyperpigmented skin and new diabetes. Which of the following is the most likely diagnosis?

Accepted Answer

Hereditary hemochromatosis

Answer

Wilson disease

Answer

Autoimmune hepatitis

Answer

Nonalcoholic fatty liver without iron overload

Answer

Alpha-1 antitrypsin deficiency

Hereditary hemochromatosis — USMLE Step 3 MCQ

A 55-year-old man has fatigue and arthralgia. Laboratory studies show AST 88 U/L, ALT 94 U/L, fasting transferrin saturation 72%, and ferritin 870 ng/mL. He has hyperpigmented skin and new diabetes. Which of the following is the most likely diagnosis?