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Unintentional weight loss — ABIM Board MCQ

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ModerateGeneral Internal MedicineUnintentional weight lossABIM Board

A 72-year-old man has confirmed iron-deficiency anemia without overt bleeding or another clear source. He is clinically stable and has never had gastrointestinal evaluation. What is the appropriate diagnostic plan?

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Correct answer: EArrange same-sitting upper endoscopy and colonoscopy while treating the iron deficiency

The best answer is “Arrange same-sitting upper endoscopy and colonoscopy while treating the iron deficiency”. Men with confirmed iron-deficiency anemia generally require bidirectional endoscopy because occult upper- or lower-GI disease, including malignancy, may be present despite absent symptoms. Iron replacement should proceed but does not replace etiologic evaluation. Capsule endoscopy is usually considered only after negative initial evaluation and an appropriate trial of treatment.

Reference: AGA 2020 Gastrointestinal Evaluation of Iron Deficiency Anemia Guideline: https://gastro.org/clinical-guidance/gastrointestinal-evaluation-of-iron-deficiency-anemia/