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Depression treatment — ABFM Board MCQ

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EasyMental healthDepression treatmentABFM Board

A 44-year-old man has moderate major depression on PHQ-9. He has no suicidal ideation, mania, or psychosis. He prefers medication and has no contraindications. Which of the following is the most appropriate initial treatment?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Start an SSRI and arrange follow-up

SSRIs are common first-line pharmacologic treatment for uncomplicated moderate major depression, with monitoring for response and adverse effects.

Reference: American Family Physician clinical reviews and AAFP guidance: https://www.aafp.org/pubs/afp.html