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Infectious mononucleosis — ABFM Board MCQ

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EasyInfectious diseaseInfectious mononucleosisABFM Board

A 19-year-old college student has fever, sore throat, fatigue, posterior cervical lymphadenopathy, and splenomegaly. Rapid strep test is negative. Which of the following is the most likely diagnosis?

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Correct answer: AEpstein-Barr virus infectious mononucleosis

Fatigue, pharyngitis, posterior cervical lymphadenopathy, and splenomegaly in a young adult suggest EBV infectious mononucleosis.

Reference: American Family Physician clinical reviews and AAFP guidance: https://www.aafp.org/pubs/afp.html