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Tricyclic antidepressant overdose — ABEM Board MCQ

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HardToxicologyTricyclic antidepressant overdoseABEM Board

A 41-year-old woman arrives after a suspected overdose. Triage acuity is ESI 1; BP 82/48 mm Hg, HR 142/min, pupils dilated, skin dry. ECG shows QRS duration 148 ms and a terminal R wave in aVR. She has a generalized seizure in the ED. Which of the following is the most likely diagnosis?

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Correct answer: CTricyclic antidepressant toxicity

Anticholinergic signs, seizure, hypotension, wide QRS, and terminal R in aVR are classic for tricyclic antidepressant poisoning.

Reference: ACMT toxicology guidance