skip to main content

VZV vasculopathy — SCE Neurology MCQ

Instant feedback + full explanation. One question, done properly.

HardCNS InfectionsVZV vasculopathySCE Neurology

A patient with drug-resistant focal epilepsy has genetically confirmed familial short-QT syndrome and a resting QTc of 338 ms. Which decision about cenobamate is most appropriate?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Select another antiseizure medicine because cenobamate can further shorten QTc

Explanation lettering: C = shown as B · E = shown as C · B = shown as E

E is correct: cenobamate can shorten QTc and is contraindicated in familial short-QT syndrome, so a different antiseizure medicine is required. A reverses the electrophysiological effect. B treats an acquired contributor but does not remove the inherited contraindication. C substitutes structural imaging for ventricular repolarisation assessment. D adds monitoring without making exposure safe. The relevant safety signal is QT shortening, not the QT prolongation familiar from many other medicines.

Reference: Ontozry 12.5 mg tablets SmPC: https://www.medicines.org.uk/emc/product/14636/smpc