Toxoplasma encephalitis — SCE Neurology MCQ
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Correct answer: E — mGluR5-associated Ophelia syndrome treated with lymphoma therapy and immunotherapy
Explanation lettering: E = shown as C · C = shown as D · D = shown as E
D is correct: mGluR5 antibody encephalitis associated with Hodgkin lymphoma is Ophelia syndrome; it is a neuronal-surface antibody disorder and can respond well to immunotherapy alongside decisive tumour treatment. A misclassifies the antibody as intracellular. B is associated with paraneoplastic cerebellar degeneration rather than limbic encephalitis. C describes LEMS. E describes a different sleep–bulbar neuroimmunological syndrome. The surface-versus-intracellular distinction predicts reversibility and treatment responsiveness.
Reference: Paraneoplastic neurological syndromes: a practical approach to diagnosis and management: https://pn.bmj.com/content/22/1/19