skip to main content

Uhthoff phenomenon — SCE Neurology MCQ

Instant feedback + full explanation. One question, done properly.

HardMSUhthoff phenomenonSCE Neurology

A patient with established multiple sclerosis notices transient recurrence of an old leg deficit during fever and hot baths; it resolves after cooling, with no new symptoms. What is the best interpretation?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Uhthoff phenomenon or pseudo-relapse from temperature-related conduction failure; identify and treat triggers before labelling a new relapse

The best answer is “Uhthoff phenomenon or pseudo-relapse from temperature-related conduction failure; identify and treat triggers before labelling a new relapse”. Brief heat-dependent worsening of old deficits is a pseudo-relapse, not evidence of new inflammatory activity. “A definite new inflammatory relapse requiring steroids immediately” is plausible in a different neurological context, but the decisive findings here argue against it. “A focal seizure requiring long-term antiseizure treatment” is plausible in a different neurological context, but the decisive findings here argue against it. “Progressive multifocal leukoencephalopathy” is plausible in a different neurological context, but the decisive findings here argue against it. “A new compressive myelopathy proven by heat sensitivity” is plausible in a different neurological context, but the decisive findings here argue against it.

Reference: NICE NG220 multiple sclerosis recommendations: https://www.nice.org.uk/guidance/ng220/chapter/Recommendations