EMG motor neurone disease — SCE Neurology MCQ

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HardNeurological InvestigationsEMG motor neurone diseaseSCE Neurology

Progressive weakness shows upper- and lower-motor-neurone dysfunction in several regions, intact sensation and widespread active and chronic denervation without conduction block. What diagnosis best fits?

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Correct answer: A — Amyotrophic lateral sclerosis or motor neurone disease

The best answer is “Amyotrophic lateral sclerosis or motor neurone disease”. UK stroke guidance supports urgent vascular imaging and reperfusion selection, short-course dual antiplatelet therapy for eligible minor stroke or high-risk TIA, decompression for life-threatening swelling, and secondary prevention matched to mechanism. The alternatives “Multifocal motor neuropathy with conduction block”, “Cervical myelopathy with a single anatomical level”, “Myasthenia gravis with fatigable weakness and normal sensation”, “Length-dependent neuropathy with distal sensory loss” are clinically adjacent possibilities, but they do not match the defining chronology, localisation, physiology, investigation result or UK management sequence in this stem.

Reference: National Clinical Guideline for Stroke: acute care: https://www.strokeguideline.org/chapter/acute-care/