A 4-year-old with genetically confirmed Dravet syndrome continues to have convulsive seizures despite adequate sodium valproate. Which is the most

Question

A 4-year-old with genetically confirmed Dravet syndrome continues to have convulsive seizures despite adequate sodium valproate. Which is the most appropriate first add-on regimen?

Accepted Answer

Add stiripentol with clobazam while continuing sodium valproate

Answer

Add ethosuximide because it is first-line for all childhood epileptic encephalopathies

Answer

Stop antiseizure therapy and manage fever avoidance alone

Answer

Add carbamazepine because sodium-channel blockade is preferred in SCN1A disease

Answer

Replace sodium valproate with phenytoin monotherapy

Dravet syndrome — SCE Neurology MCQ

A 4-year-old with genetically confirmed Dravet syndrome continues to have convulsive seizures despite adequate sodium valproate. Which is the most appropriate first add-on regimen?