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Hepatitis B non-responder management — DOccMed MCQ

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ModerateInfection ControlHepatitis B non-responder managementDOccMed

A 27-year-old healthcare worker has completed a primary course of hepatitis B vaccination but her anti-HBs level is 8 mIU/ml (below 10). What is the most appropriate management?

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Correct answer: E — She should receive up to one further complete course and be retested, and if she remains a non-responder after two full courses, she should be tested for HBsAg and managed according to the result

An anti-HBs below 10 mIU/ml after a primary course indicates inadequate response. A further complete course should be offered. If still non-responsive after two courses, HBsAg testing is required to exclude chronic carriage. Non-responders who are HBsAg negative can perform EPPs but require special protocols if exposed.

Reference: PHE Green Book; DH Health Clearance