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Ovarian cancer symptoms — DRCOG MCQ

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HardGynaecological OncologyOvarian cancer symptomsDRCOG

A 63-year-old has persistent abdominal distension, early satiety and urinary frequency. Examination is normal. What is the first investigation recommended in primary care?

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Correct answer: A — Serum CA125 measurement from a blood sample

The best answer is “Serum CA125 measurement from a blood sample”. Persistent bloating, early satiety and urinary frequency can suggest ovarian cancer, particularly in people over 50. NICE recommends serum CA125 as the first investigation in primary care; when it is 35 kU/L or more, ultrasound of the abdomen and pelvis follows.

Reference: NICE CG122: Ovarian cancer recognition and initial management: https://www.nice.org.uk/guidance/cg122/chapter/recommendations