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Premature ovarian insufficiency — DRCOG MCQ

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ModerateGynaecologyPremature ovarian insufficiencyDRCOG

A 36-year-old woman has amenorrhoea for 6 months, hot flushes and vaginal dryness. Pregnancy test is negative and she is not using hormonal contraception. She asks whether this could be early menopause. What is the most appropriate investigation?

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Correct answer: B — Measure FSH on two occasions 4 to 6 weeks apart

Suspected premature ovarian insufficiency in a woman under 40 is investigated with FSH testing on two occasions 4 to 6 weeks apart. Clinical diagnosis without testing is suitable for many women over 45, not this age group. CA125 and cervical cytology do not diagnose ovarian insufficiency. Management should include discussion of HRT and fertility implications if confirmed.

Reference: NICE NG23