Raised CA125 — DRCOG MCQ

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HardGynaecological OncologyRaised CA125DRCOG

A 58-year-old has persistent bloating and CA125 62 IU/mL. She is stable with no acute pain. What is the most appropriate next investigation?

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Correct answer: A — Arrange ultrasound of the abdomen and pelvis

For symptoms suggesting ovarian cancer, NICE recommends CA125 testing and ultrasound of the abdomen and pelvis if CA125 is 35 IU/mL or greater. Imaging then guides appropriate referral and further assessment.

Reference: NICE CG122: Ovarian cancer recognition and initial management: https://www.nice.org.uk/guidance/cg122/chapter/Recommendations