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PONV with QT risk — FRCA Primary MCQ

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EasyPharmacologyPONV with QT riskFRCA Primary

A patient with congenital long QT needs antiemetic planning after laparoscopy. Which drug is the main QT-prolonging antiemetic to use cautiously?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Ondansetron

Ondansetron can prolong the QT interval and requires caution in congenital long QT. Atracurium is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Clopidogrel is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Pancuronium is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Morphine is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. In Primary FRCA pharmacology, link the clinical effect to the receptor, distribution or elimination mechanism rather than memorising isolated facts.

Reference: Peck, Hill & Williams Pharmacology for Anaesthesia and Intensive Care; BNF; Primary FRCA textbooks