Dabigatran reversal — FRCA Primary MCQ
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Correct answer: D — Idarucizumab
Idarucizumab is a monoclonal antibody fragment that specifically reverses dabigatran anticoagulation. Naloxone is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Clopidogrel is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Dantrolene is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Dobutamine is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. In Primary FRCA pharmacology, link the clinical effect to the receptor, distribution or elimination mechanism rather than memorising isolated facts.
Reference: Peck, Hill & Williams Pharmacology for Anaesthesia and Intensive Care; BNF; Primary FRCA textbooks