Loop diuretic pulmonary oedema — FRCA Primary MCQ

Correct answer: E — Furosemide

Furosemide inhibits the Na-K-2Cl cotransporter in the thick ascending limb, producing loop diuresis. Naloxone is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Four-factor prothrombin complex concentrate with vitamin K is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Ephedrine is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Neostigmine is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. In Primary FRCA pharmacology, link the clinical effect to the receptor, distribution or elimination mechanism rather than memorising isolated facts.

Reference: Peck, Hill & Williams Pharmacology for Anaesthesia and Intensive Care; BNF; Primary FRCA textbooks