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Heparin reversal — FRCA Primary MCQ

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EasyPharmacologyHeparin reversalFRCA Primary

After unfractionated heparin for vascular surgery, the activated clotting time remains prolonged with bleeding. Which drug is most appropriate?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Protamine

Protamine reverses unfractionated heparin. Ondansetron is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Dantrolene is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Sugammadex is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Atracurium is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. In Primary FRCA pharmacology, link the clinical effect to the receptor, distribution or elimination mechanism rather than memorising isolated facts.

Reference: Peck, Hill & Williams Pharmacology for Anaesthesia and Intensive Care; BNF; Primary FRCA textbooks