skip to main content

Clopidogrel antiplatelet effect — FRCA Primary MCQ

Instant feedback + full explanation. One question, done properly.

ModeratePharmacologyClopidogrel antiplatelet effectFRCA Primary

A patient with a recent coronary stent has reduced ADP-mediated platelet aggregation. Which drug is most likely responsible?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Clopidogrel

Clopidogrel is a P2Y12 receptor antagonist that reduces ADP-mediated platelet activation. Bupivacaine is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Propofol is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Noradrenaline is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Salbutamol is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. In Primary FRCA pharmacology, link the clinical effect to the receptor, distribution or elimination mechanism rather than memorising isolated facts.

Reference: Peck, Hill & Williams Pharmacology for Anaesthesia and Intensive Care; BNF; Primary FRCA textbooks