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Fetal haemoglobin — FRCA Primary MCQ

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ModeratePhysiologyFetal haemoglobinFRCA Primary

A neonate has a left-shifted oxygen dissociation curve compared with an adult. What is the most likely explanation?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: CHypothermia shifts the oxyhaemoglobin curve left

Fetal haemoglobin has higher oxygen affinity than adult haemoglobin. Reduced baroreceptor firing increases sympathetic outflow is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Increased preload increases stroke volume through fibre stretch is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Aldosterone increases sodium reabsorption and potassium secretion is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Chronic hypertension shifts cerebral autoregulation right is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. In Primary FRCA physiology, the correct answer is usually the variable that best explains the observed change in the anaesthetised patient.

Reference: West's Respiratory Physiology; Ganong Review of Medical Physiology; Primary FRCA textbooks