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Ondansetron after laparoscopy — FRCA Primary MCQ

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HardPharmacologyOndansetron after laparoscopyFRCA Primary

A patient at high risk of PONV receives a 5-HT3 antagonist after laparoscopy. Which drug is most likely?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Ondansetron

Ondansetron is a 5-HT3 antagonist used for PONV prophylaxis and treatment. Salbutamol is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Glycopyrronium is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Ephedrine is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Adenosine is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. In Primary FRCA pharmacology, link the clinical effect to the receptor, distribution or elimination mechanism rather than memorising isolated facts.

Reference: Peck, Hill & Williams Pharmacology for Anaesthesia and Intensive Care; BNF; Primary FRCA textbooks