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Bohr effect — FRCA Primary MCQ

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ModeratePhysiologyBohr effectFRCA Primary

A shocked patient with lactic acidosis unloads oxygen more readily at tissue level. What is the most likely explanation?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: CAcidosis shifts the oxyhaemoglobin curve right

Acidosis shifts the oxyhaemoglobin dissociation curve to the right. Renin rises with reduced afferent arteriolar pressure is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Perfusion of non-ventilated alveoli creates shunt is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Hypoxic pulmonary vasoconstriction diverts blood flow is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Closing capacity exceeding FRC causes airway closure is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. In Primary FRCA physiology, the correct answer is usually the variable that best explains the observed change in the anaesthetised patient.

Reference: West's Respiratory Physiology; Ganong Review of Medical Physiology; Primary FRCA textbooks