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Propofol hypotension — FRCA Primary MCQ

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HardPharmacologyPropofol hypotensionFRCA Primary

A patient develops apnoea and vasodilation immediately after induction with a lipid emulsion. Which drug is most likely?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: APropofol

Propofol commonly causes dose-dependent respiratory depression and hypotension. Etomidate is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Glycopyrronium is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Dantrolene is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. Ondansetron is less appropriate because it would fit a different clinical clue or a separate anaesthetic problem. In Primary FRCA pharmacology, link the clinical effect to the receptor, distribution or elimination mechanism rather than memorising isolated facts.

Reference: Peck, Hill & Williams Pharmacology for Anaesthesia and Intensive Care; BNF; Primary FRCA textbooks