Sjögren syndrome — MCCQE Part 1 MCQ

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ModerateFatigueSjögren syndromeMCCQE Part 1

A 50-year-old woman has progressive fatigue, dry eyes/mouth, positive ANA, anti-Ro (SSA), and anti-La (SSB). Schirmer test <5mm. Most likely diagnosis?

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Correct answer: B — Primary Sjögren syndrome

Sicca symptoms (dry eyes + dry mouth) + anti-Ro/La + low Schirmer test = primary Sjögren. Risk of lymphoma (MALT). Monitor for extraglandular manifestations. Symptomatic treatment: artificial tears, pilocarpine.

Reference: Canadian Rheumatology Association