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Alzheimer's disease — MCCQE Part 1 MCQ

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EasyMemory LossAlzheimer's diseaseMCCQE Part 1

A 72-year-old woman has progressive memory loss, word-finding difficulty, getting lost, personality changes x 2 years. MMSE 18/30. CT: generalised cortical atrophy. Most appropriate initial pharmacotherapy?

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Correct answer: D — Cholinesterase inhibitor (donepezil, rivastigmine, or galantamine)

Probable Alzheimer's (mild-moderate): cholinesterase inhibitors first-line. Modest symptomatic benefit. Memantine for moderate-severe (MMSE <20, can add to ChEI). Antipsychotics increase stroke/mortality risk in dementia.

Reference: CCCDTD / 4th Canadian Consensus on Dementia