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Bipolar I (acute mania) — MCCQE Part 1 MCQ

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ModerateMania/BipolarBipolar I (acute mania)MCCQE Part 1

A 45-year-old man has slept only 2-3h/night x 10 days, bought two cars he cannot afford, speaks rapidly, grandiose plans. No substance use. No prior psych history. Most appropriate initial treatment?

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Correct answer: DMood stabiliser (lithium) or atypical antipsychotic (quetiapine/olanzapine)

Acute mania: CANMAT recommends lithium, valproate, or atypical antipsychotic first-line. Antidepressant without mood stabiliser CONTRAINDICATED — can worsen mania. Likely requires hospitalisation.

Reference: CANMAT Bipolar 2024