skip to main content

Major depressive disorder — MCCQE Part 1 MCQ

Instant feedback + full explanation. One question, done properly.

EasyDepressionMajor depressive disorderMCCQE Part 1

A 35-year-old man has depressed mood, anhedonia, insomnia, fatigue, poor concentration, worthlessness, and passive SI x 3 weeks. No prior psych history. Normal exam and bloods. Most appropriate initial management?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — SSRI (sertraline or escitalopram) plus psychotherapy referral

Moderate MDD: CANMAT recommends SSRI/SNRI first-line + psychotherapy (CBT/IPT). Sertraline and escitalopram have best efficacy/tolerability evidence. Benzodiazepines not for depression.

Reference: CANMAT Depression 2024