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Minimal change disease — MCCQE Part 1 MCQ

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ModerateEdemaMinimal change diseaseMCCQE Part 1

A 10-year-old boy has periorbital oedema and frothy urine x 2 weeks. Normal BP. Urine: 4+ protein, no blood. Albumin 15 g/L, elevated cholesterol. Normal creatinine. Most likely diagnosis?

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Correct answer: E — Minimal change disease (nephrotic syndrome)

Nephrotic syndrome in child 1-10: ~80% minimal change disease. CPS: trial of corticosteroids without biopsy for typical first presentation. Biopsy for steroid-resistant, atypical, or age <1/>12.

Reference: CPS Paediatric Nephrology